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Dr. Alessandro Ciresi

Il Dr. Alessandro Ciresi è medico specialista in Endocrinologia e Malattie del Ricambio, laureato presso l’Università degli Studi di Palermo, dove ha anche conseguito la specializzazione. Ha svolto attività di ricerca su patologie endocrino-metaboliche, in particolare sulle malattie ipofisarie e il diabete mellito, ricoprendo il ruolo di assegnista di ricerca e ricercatore universitario. È stato docente presso diversi corsi di laurea e alla Scuola di Specializzazione in Endocrinologia e Malattie del Metabolismo. Autore di numerose pubblicazioni scientifiche su riviste nazionali e internazionali, è membro della Società Italiana di Endocrinologia (SIE), della Società Italiana di Endocrinologia Pediatrica (SIEDP) e del Gruppo di studio SIE “malattie ipotalamo-ipofisarie”.

  1. A Ciresi, MC Amato, A Criscimanna, A Mattina, C Vetro, A Galluzzo, G D’Acquisto and C Giordano Metabolic parameters and adipokine profile during GH replacement therapy in children with GH deficiencyEur J Endocrinol, 2007; 156: 353—360 DOI: 10.1530/eje.1.02343 
  2. MC Amato, A Ciresi, P Richiusa, A Criscimanna, L Allotta, A Mattina, A Galluzzo, C Giordano Relative Hypoleptinemia in Poorly Controlled Patients with Type 1 Diabetes Horm Metab Res 2007; 39: 398-399 
  3. Ciresi A., Amato M.C., Vetro C., Lo Coco R., Galluzzo A., Giordano C. Adrenal morphology and function in acromegalic patients in relation to disease activity  Endocrine,  2009 Oct; 36(2): 346-54 
  4. A. Ciresi, M.C. Amato, D. Morreale, R. Morreale, F. Di Giovanna, S. Carità, G. Lodato, A. Galluzzo, C. Giordano OCT is not useful for detection of minimal diabetic retinopathy in Type 1 Diabetes Acta Diabetologica, 2010 Sep;47(3): 259-63 
  5. A. Ciresi, M.C. Amato, D. Morreale, G. Lodato, A. Galluzzo and C. Giordano Cornea in acromegalic patients as a possible target of GH action Journal of Endocrinological Investigation, 2011 Feb; 34(2): e30-5 
  6. A.Ciresi, M.C.Amato, A.Galluzzo, C.Giordano Complete biochemical control and pituitary adenoma disappearance in a child with gigantism: efficacy of octreotide therapy Journal of Endocrinological Investigation, 2011 Feb; 34(2): 162-3 
  7. Cambuli V, Galdiero M, Mastinu M, Auriemma R, Ciresi A, Pivonello R, Amato M, Giordano C, Mariotti S, Colao A, Baroni M.  Glycometabolic control in Acromegalic patients with Diabetes: a study of the effects of different treatments for GH excess and for hyperglycaemia Journal of Endocrinological Investigation, 2012 Feb; 35(2): 154-9 
  8. C.Giordano, M.C.Amato, A.Ciresi, R.Citarrella, L.Mantione,  M.Accidenti, A.Mattina, G.D’Acquisto, F.Pantò, A.Criscimanna, A.Galluzzo. Predictors of microvascular complications in type 1 diabetic patients at onset: the role of metabolic memory.European Journal of Internal Medicine, 2011 Jun;22(3): 266-74 
  9. Giordano C, Ciresi A, Amato MC, Pivonello R, Auriemma RS, Grasso LF, Galluzzo A, Colao A. Clinical and metabolic effects of first-line treatment with somatostatin analogues or surgery in acromegaly: a retrospective and comparative study. Pituitary. 2012 Dec; 15(4): 539-51 
  10. A. Ciresi, V. Guarnotta, L. Tomasello, V. Calò, A. Russo, A. Galluzzo, C. Giordano. Janus kinase (JAK) 2 V617F mutation as the cause of primary thrombocythemia in acromegaly with severe visceromegaly and divergence between growth hormone and insulin-like growth factor-1 concentrations during the follow-up: causal or casual association? Growth Hormone & IGF Research. 2012 Apr; 22(2): 92-6 
  11. Ciresi A, Amato MC, Pizzolanti G, Giordano Galluzzo C. Visceral Adiposity Index Is Associated with Insulin Sensitivity and Adipocytokine Levels in Newly Diagnosed Acromegalic Patients. J Clin Endocrinol Metab. 2012 Aug; 97(8): 2907-15 
  12. Ciresi A, Amato MC, Pivonello R, Nazzari E, Grasso LF, Minuto F, Ferone D, Colao A, Giordano C. The Metabolic Profile in Active Acromegaly is Gender-Specific. J Clin Endocrinol Metab. 2013 Jan; 98(1): E51-9
  13. Ciresi A, Amato MC, Guarnotta V, Lo Castro F, Giordano C. Higher doses of cabergoline further improve metabolic parameters in patients with prolactinoma regardless of the degree of reduction in prolactin levels. Clin Endocrinol (Oxf). 2013 Dec;79(6):845-52 
  14. Giordano C, Guarnotta V, Pivonello R, Amato MC, Simeoli C, Ciresi A, Cozzolino A,  Colao A. Is diabetes in Cushing’s syndrome only a consequence of hypercortisolism? Eur J Endocrinol. 2013 Dec 21; 170(2): 313-21 
  15. Amato MC, Guarnotta V, Ciresi A, Modica R, Pantò F, Giordano C. No Phenotypic Differences for Polycystic Ovary Syndrome (PCOS) Between Women With and Without Type 1 Diabetes Mellitus. J Clin Endocrinol Metab. 2014 Jan; 99(1): 203-11 
  16. Ciresi A, Guarnotta V, Amato MC, Giordano C. Correlation between Severity of Growth Hormone Deficiency and Thyroid Metabolism and Effects of Long-Term Growth Hormone Treatment on Thyroid Function in Children with Idiopathic Growth Hormone Deficiency. Horm Res Paediatr. 2014;81(6):379-85. 
  17. Ciresi A, Cicciò F, Giordano C. High prevalence of hypovitaminosis D in Sicilian children affected by growth hormone deficiency and its improvement after 12 months of replacement treatment. J Endocrinol Invest. 2014 Jul;37(7):631-8 
  18. Ciresi A, Morreale R, Radellini S, Cillino S, Giordano C. Corneal thickness in children with growth hormone deficiency: The effect of GH treatment. Growth Horm IGF Res. 2014 Aug;24(4):150-4 
  19. Ciresi A, Amato MC, Giordano C. Reduction in insulin sensitivity and inadequate β-cell capacity to counteract the increase in insulin resistance in children with idiopathic growth hormone deficiency during 12 months of growth hormone treatment. J Endocrinol Invest. 2015 Mar;38(3):351-9 
  20. Di Somma C*, Ciresi A*, Amato MC, Savastano S, Savanelli MC, Scarano E, Colao A, Giordano C. (*equal contributions)Alteration of the growth hormone axis, visceral fat dysfunction, and early cardiometabolic risk in adults: the role of the visceral adiposity index. Endocrine 2015 Jun;49(2):492-502 
  21. Benfante A, Ciresi A, Bellia M, Cannizzaro F, Bellia V, Giordano C, Scichilone N. Early Lung Function Abnormalities in Acromegaly. Lung. 2015 Jun;193(3):393-9. 
  22. Ciresi A, Cicciò F, Amato MC, Giordano C. Revaluation of the clinical and metabolic behavior of children with isolated growth hormone deficiency during GH treatment according to newly proposed note 39 of the Italian Medicines Agency (AIFA). J Endocrinol Invest. 2015 Dec;38(12):1301-7 
  23. Ciresi A, Amato MC, Pizzolanti G, Giordano C. Serum visfatin levels in acromegaly: correlation with disease activity and metabolic alterations. Growth hormone & IGF Research, 2015 
  24. Amato MC, Vesco R, Vigneri E, Ciresi A, Giordano C. Hyperinsulinism and polycystic ovary syndrome (PCOS): role of insulin clearance. J Endocrinol Invest. 2015 Dec;38(12):1319-26 
  25. Ciresi A, Amato MC, Bianco J, Giordano C. Prevalence and clinical features of polycystic ovarian syndrome in adolescents with previous childhood growth hormone deficiency. J Pediatr Endocrinol Metab. 2016 May 1;29(5):571-8.
  26. Guarnotta V, Amato MC, Pivonello R, Arnaldi G, Ciresi A, Trementino L, Citarrella R, Iacuaniello D, Michetti G, Simeoli C, Colao A, Giordano C. The degree of urinary hypercortisolism is not correlated with the severity of Cushing’s syndrome.Endocrine. 2017 Feb;55(2):564-572. 
  27. Ciresi A, Pizzolanti G, Leotta M, Guarnotta V, Teresi G, Giordano C. Resistin, visfatin, leptin and omentin are differently related to hormonal and metabolic parameters in growth hormone-deficient children. J Endocrinol Invest. 2016 Sep;39(9):1023-30. 
  28. Ciresi A, Cicciò F, Radellini S, Giordano C. Utility of C-peptide for a reliable estimate of insulin secretion in children with growth hormone deficiency. Growth Horm IGF Res. 2016 May 9;29:71-77. 
  29. Ciresi A, Radellini S, Guarnotta V, Giordano C. The visceral adiposity index is associated with insulin sensitivity and IGF-I levels in adults with growth hormone deficiency. Endocrine. 2017 Jun;56(3):579-588. 
  30. Guarnotta V, Riela S, Massaro M, Bonventre S, Inviati A, Ciresi A, Pizzolanti G, Benvenga S, Giordano C. The Daily Consumption of Cola Can Determine Hypocalcemia: A Case Report of Postsurgical hypoparathyroidism-Related Hypocalcemia Refractory to Supplemental Therapy with High Doses of Oral Calcium. Front Endocrinol (Lausanne). 2017 Jan 26;8:7
  31. Guarnotta V, Ciresi A, Pitrone M, Pizzolanti G, Giordano C. Pasireotide versus pituitary surgery: a retrospective analysis of 12 months of treatment in patients with Cushing’s disease. Endocrine. 2017 Mar 17. 
  32. Ciresi A, Giordano C. GHD come predittore di sindrome metabolica. L’Endocrinologo, 2017. 
  33. Ciresi A, Giordano C. Vitamin D across growth hormone (GH) disorders: From GH deficiency to GH excess. Growth Horm IGF Res. 2017 Apr;33:35-42. 
  34. Ciresi A, Cicciò F, Radellini S, Guarnotta V, Calcaterra AM, Giordano C. More Favorable Metabolic Impact of Three-Times-Weekly versus Daily Growth Hormone Treatment in Naïve GH-Deficient Children. Int J Endocrinol. 2017;2017:8469680.
  35. Ciresi A, Radellini S, Vigneri E, Guarnotta V, Bianco J, Mineo MG, Giordano C. Correlation between adrenal function, growth hormone secretion, and insulin sensitivity in children with idiopathic growth hormone deficiency. J Endocrinol Invest. 2017 Aug 18. 
  36. Bagnasco F, Di Iorgi N, Roveda A, Gallizia A, Haupt R, Maghnie M; Adherence Investigators Group * Prevalence and correlates of adherence in children and adolescents treated with growth hormone: a multicenter italian study. Endocr Pract. 2017 Aug;23(8):929-941. 
  37. Alessandro Ciresi, Enrica Vigneri, Stefano Radellini, Felicia Panto`, Carla Giordano. Liraglutide Improves Cardiovascular Risk as an Add-on to Metformin and Not to Insulin Secretagogues in Type 2 Diabetic Patients: A Real-life 48-Month Retrospective Study. Diabetes Ther. 2018 Feb;9(1):363-371. 
  38. Petta S, Ciresi A, Bianco J, Geraci V, Boemi R, Galvano L, Magliozzo F, Merlino G, Craxì A, Giordano C. Insulin resistance and hyperandrogenism drive steatosis and fibrosis risk in young females with PCOS. PLoS One. 2017 Nov 21;12(11):e0186136. 
  39. Ciresi A, Giordano C. One-hour post-load plasma glucose level is associated with a worse metabolic profile in children with GH deficiency. J Endocrinol Invest. 2017 Dec 16
  40. Ciresi A, Guarnotta V, Pizzolanti G, Giordano C. Comparison between euglycemic hyperinsulinemic clamp and surrogate indices of insulin sensitivity in children with growth hormone deficiency. Growth Horm IGF Res. 2017 Dec 13. pii: S1096-6374(17)30116-8.
  41. Ciresi A, Radellini S, Guarnotta V, Giordano C. Efficacy of combined treatment with pasireotide, pegvisomant and cabergoline in an acromegalic patient resistant to other treatments: a case report. BMC Endocr Disord. 2018 Jan 24;18(1):2. 
  42. Guarnotta V, Ciresi A, Pillitteri G, Giordano C. Improved insulin sensitivity and secretion in pre-diabetic patients with adrenal insufficiency on dual-release hydrocortisone treatment: a 36-month retrospective analysis. Clin Endocrinol (Oxf). 2018 Jan 25. 
  43. Albani A, Ferraù F, Ciresi A, Pivonello R, Scaroni C, Iacuaniello D, Zilio M, Guarnotta V, Alibrandi A, Messina E, Boscaro M, Giordano C, Colao A, Cannavo S. Pasireotide treatment reduces cardiometabolic risk in Cushing’s disease patients: an Italian, multicenter study. Endocrine. 2018 Jan 30. 
  44. Guarnotta V, Pizzolanti G, Ciresi A, Giordano C. Insulin sensitivity and secretion and adipokine profile in patients with Cushing’s disease treated with pasireotide. J Endocrinol Invest. 2018 Feb 2. 
  45. Cilluffo G, Ferrante G, Fasola S, Ciresi A, Cardillo I, Tancredi G, Viegi G, Giordano C, Scichilone N, La Grutta S. Direct and indirect effects of Growth Hormone Deficiency (GHD) on lung function in children: A mediation analysis. Respir Med. 2018 Apr;137:61-69. 
  46. Guarnotta V, Vigneri E, Pillitteri G, Ciresi A, Pizzolanti G, Giordano C. Higher cardiometabolic risk in idiopathic versus autoimmune type 1 diabetes: a retrospective analysis. Diabetol Metab Syndr. 2018 May 10;10:40. 
  47. Ciresi A, Radellini S, Guarnotta V, Mineo MG, Giordano C. The metabolic outcomes of growth hormone treatment in children are gender-specific. Endocr Connect. 2018 Jun 20. pii: EC-18-0135. 
  48. Ciresi A, Giordano C. Glucose Metabolism in Children With Growth Hormone Deficiency. Front Endocrinol (Lausanne). 2018 Jun 11;9:321. 
  49. Barbot M, Guarnotta V, Zilio M, Ceccato F, Ciresi A, Daniele A, Pizzolanti G, Campello E, Frigo AC, Giordano C, Scaroni C. Effects of pasireotide treatment on coagulative profile: a prospective study in patients with Cushing’s disease. Endocrine. 2018 Jul 6. 
  50. Ferraù F, Albani A, Ciresi A, Giordano C, Cannavò S. Diabetes Secondary to Acromegaly: Physiopathology, Clinical Features and Effects of Treatment. Front Endocrinol (Lausanne). 2018 Jul 6;9:358. 
  51. Ciresi A, Piazza G, Radellini S, Guarnotta V, Mineo MG, Giordano C. Growth hormone and hematopoiesis: A retrospective analysis on a large cohort of children with growth hormone deficiency. Growth Horm IGF Res. 2018 Jul 20;42-43:8-13. 
  52. Guarnotta V, Di Bella G, Pillitteri G, Ciresi A, Giordano C. Improved Cardiovascular and Cardiometabolic Risk in Patients With Type 1 Diabetes and Autoimmune Polyglandular Syndrome Switched From Glargine to Degludec Due to Hypoglycaemic Variability. Front Endocrinol (Lausanne). 2018 Jul 26;9:428. 
  53. Ciresi A, Pizzolanti G, Guarnotta V, Giordano C. Circulating irisin levels in children with growth hormone (GH) deficiency before and after 1 year of GH treatment. J Clin Endocrinol Metab. 2018 Nov 9. 
  54. Ciresi A, Guarnotta V, Campo D, Giordano C. Hepatic Steatosis Index in Acromegaly: Correlation with Insulin Resistance Regardless of the Disease Control. Int J Endocrinol. 2018 Dec 19;2018:5421961. 
  55. Guarnotta V, Di Stefano C, Santoro A, Ciresi A, Coppola A, Giordano C. Dual-release hydrocortisone vs conventional glucocorticoids in adrenal insufficiency. Endocr Connect. 2019 Jul 1;8(7):853-862. 
  56. Gagliardo C, Radellini S, Morreale Bubella R, Falanga G, Richiusa P, Vadalà M, Ciresi A, Midiri M, Giordano C. Lacrimal gland herniation in Graves ophthalmopathy: a simple and useful MRI biomarker of disease activity. Eur Radiol. 2020 Jan 17. 

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